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Clinical Trail Management India

He talked at size on the Indian Pharmacovigilance Program and also motivated Medical specialists to be proactively included in reporting unfavorable medication occasions. Mr. Mahesh presented MakroCare as well as described concerning the opening up of Indian markets for professional study. Teacher, Clinical Pharmacology & Therapeutics, Nizam’s Institute of Medical Sciences, Hyderabad invited the delegates as well as contrast the program.

He talked at size on the Indian Pharmacovigilance Program as well as motivated Medical experts to be proactively entailed in reporting damaging medicine occasions. Mr. Mahesh presented MakroCare and also clarified concerning the opening up of Indian markets for medical study. Teacher, Clinical Pharmacology & Therapeutics, Nizam’s Institute of Medical Sciences, Hyderabad invited the delegates and also contrast the program. The business supplies website option, individual employment, job as well as information monitoring, medical surveillance, high quality guarantee, medical writing, PMS/PharmacoVigilance, biometrics, as well as regulative support.

Online Reputation Management For Dentists Actually Works

One could really go for working with the solutions of an expert SEO firm that specialize in the art of on the internet credibility administration or brand name structure. Also hoteliers are significantly going the ‘on-line track record’ means to increase their sales via employing the solutions of a reputed branding firm in United States. Dental expert on-line track record monitoring solution is a favored electronic advertising and marketing service that aids customers protect a favorable existence online.

One could in fact go for working with the solutions of a specialist SEO firm that specialize in the art of on-line credibility monitoring or brand name structure. Also hoteliers are significantly going the ‘on-line track record’ method to enhance their sales with working with the solutions of a reputed branding firm in United States. Dental professional on-line credibility administration solution is a recommended electronic advertising and marketing option that aids customers safeguard a favorable existence online.

Chiropractic Therapy For The Management of Seizure Activity in Autistic Children

Autism is becoming more and more common in children and according to CDC reports, almost 1 in every 88 children suffers from autistic specific disorder ASD (making an overall prevalence of about 1% in United States). It has been reported that almost 33% (one-third) of all autistic children have a tendency of developing epilepsy. Besides autism, almost 2 million Americans suffer from a seizure disorder as a result of trauma, surgery, injury or congenital or acquired defects of spinal region (or brain) that may present with epilepsy (almost 1,25,000 new epilepsy cases are reported each year) that can affect the quality of life and is an economic burden on the society.

Epilepsy refers to an increase tendency in patients to develop seizures. Seizure activity is the physical manifestation of uncoordinated, excessive nervous activity (marked by excessive neural discharge) in brain. The increase in nervous activity may last for seconds or may be a minute; however, physical manifestations may vary depending upon the area of brain affected.

Seizure activity affects 1% of all autistic children at about 1 year of age and as the baby grows, the risk of seizure activity increases (at 5 year of age, the risk is 15% and at 10 years, risk increases to 25%). Ironically, as the child grows, the risk increases progressively and only 15% show a mild degree of remission in adulthood. During a seizure activity, the baby may develop involuntary and violent limb activity, generalized shaking movements of the body, tongue biting, incontinence of urine or feces, changes in behavior and alteration in the level of consciousness post-seizure. Seizure activity in any individual (regardless of age, sex or genetic composition) carries a significant risk of complications that may prove life threatening due to aspiration of gastric contents.

Chiropractic manipulation is a helpful method for the management of seizure activity in autistic children as evidenced by a number of research studies and clinical trials conducted worldwide. Subluxation of the spine is one of the frequently reported issues in autistic children and it is associated with the abnormal flow of information and nervous activity in the form of nerve impulses that may increase the risk of seizures.

Chiropractic adjustment helps in the correction of subluxation of the spine that reconnects the brain and spinal cord with rest of the body and allows uninterrupted flow of nervous activity. RA Pistolese discusses the results of his research conducted on 17 pediatric aged children and revealed that 15 of 17 patients recovered after upper cervical correction by chiropractic manipulation for correction of cervical subluxation.

Chiropractic therapy is equally effective in children as well as adults and for the management of primary issues leading to epilepsy other than autism. J. Alcantara reported another case study of a 21 year old female who was a known case of grand-mal seizure activity and chronic backaches. Her evaluation revealed spinal subluxation at 3 locations and severe impairment of spinal neuronal connectivity indicated by multiple and frequent episodes of seizures in one day. Her chiropractor performed low amplitude, high velocity manipulation along the 3 spinal locations and almost 1.5 year post-therapy, the female reported complete resolution of her back pain and tremendous improvement in the seizures (with latent period of as high as 2 months in between the seizure activity).

Chiropractic therapy is also helpful in managing a number of other neurological issues besides seizure activity. Spinal subluxation is a cause of many evident or hidden medical or neurological issues that include depression, sleep disorder, bipolar disorder, migraine headaches and mood disorders. Other than that, chiropractic therapy helps in relieving chronic pain syndromes and improves physical range of motion and systemic diseases like diabetes and hypertension.

For best results, it is better to speak to your healthcare professional regarding the potential benefits of chiropractic therapy in your loved-ones. Chiropractic care is an emerging non-pharmaceutical approach to manage and treat epileptic seizures in pediatric aged children and young adults.

Dementia Causes Symptoms & Management Methods

Dementia Causes Symptoms & Management Methods
Dementia is an umbrella term used to describe a set of specific and general symptoms which include a progressive mental decline of cognitive functioning that impacts a person’s normal daily is not classified as a disease, per se,but rather as a syndrome which includes characteristic signs and symptoms. These signs also include actual physical deterioration of the brain which leads to the cognitive deterioration, as well as reduced physical mobility.
There are many different types of dementia for which they mostly fall under two categories: primary dementia and secondary dementia.Primary dementia does not result from any other disease.Secondary dementia is caused by another disease or illness which also leads to dementia like two most common forms of dementia are Alzheimer’s Disease (AD) with 60-percent of all dementia cases, and Vascular Dementia which accounts for 20-percent.
Causes of Dementia
There are many different causes of dementia, which often result because of external or internal damage or changes to the most common causes of dementia include:
>> Diseases such as Alzheimer’s disease, Parkinson’s disease, and strokes.
>> Diseases that affect blood flow and circulation (vascular disease)
>> Excessive consumption of drugs and alcohol
>> Vitamin B12 and folate deficiency
>> Infections such as AIDS, or Creutzfeld Jacob’s disease
>> Infections to other organs
>> Head injuries and trauma
>> Thyroid problems, hypoglycemia.
>> Bleeding on the brain, or fluid accumulation on the brain
>> Poisoning
>> Inadequate supply of oxygen to the brain
>> High cholesterol and atherosclerosis (clogged arteries)
Symptoms of Dementia
Recognition of symptoms early on can lead to better management of dementia and improve the general quality of life for the of the most common signs and symptoms of dementia are:
>> Memory loss and memory confusion
>> Feeling of disorientation
>> Reduced ability to communicate
>> Inability to think in specific terms
>> Confusion or inability to perform familiar tasks
>> Mood and behavioral changes
>> Confusion over the location of personal items and familiar places
>> Decrease in personal initiative
>> Personality changes.
Management of Dementia
Unfortunately, there is no cure for primary dementia and Alzheimer’s disease which can only be managed with palliative care which brings some relief of symptoms. Management for dementia falls under three main categories: pharmacotherapy,nonpharmacological therapy, and improved caregiver services.
Treatment for dementia with the use of drugs and medication is aimed at three categories of symptoms,to improve brain functioning and cognition,to treat behavioral symptoms, and for pain management.Although dementia is not reversible, doctors will look at whether or not the decline in mental functioning is the result of other conditions which are treatable. This could include conditions such as: deficiency in vitamin B and folic acid, decreased supply of oxygen, thyroid problems, infections, anemia,depression and heart conditions.
When these conditions are not present, and the onset of symptoms is due to primary dementia,the doctor may prescribed medication that is FDA approved for dementia and Alzheimer’s, and/or medication that is prescribed “off-label” to treat dementia,and dementia related secondary symptoms.
Four medicines classified as acetylcholinesterase inhibitors have been approved by the FDA for dementia by Alzheimer’s and include: Tacrine (Cognex??), donepezil (Aricept??), galantamine (Razadyne??), and rivastigmine (Exelon??).In clinical studies, donepezil, rivastigmine, and galantamine have been shown to mildly slow the rate of cognitive decline and improve activities of daily living (ADLs) and behavior in mild-to-moderate Alzheimer disease for a period of 6-18 months.
Of these four acetylcholinesterase inhibitors, donepezil is the most prescribed and has shown to be the most effective but side-effects occur in approximately 17 percent of patients with the 5-10mg dosages. Donepezil is expected to delay the onset of AD for about one year in people suffering from mild cognitive impairment (MCI). Rivastigmine was also effective but side-effects occurred in approximately 50 percent of patients for the 6-12mg dosages, with 25 percent needing to be taken off the drug. It is also approved for Parkinson’s disease dementia by the FDA.
Memantine (Namenda) is a drug of a different class and works best in patients with moderate to severe Alzheimer’s. However, the addition of memantine to the above mentioned acetylcholinesterase inhibitors being given to mild to moderate alzheimer’s patients was no more effective than placebo.
Depression, agitation, paranoia, and anxiety are common symptoms associated with dementia and Alzheimer’s. Doctors may prescribe anti-depressants and anti-anxiety medication as well as anti-psychotics.
Dementia patients have many of the same physical ailments as non-dementia seniors to include chronic, persistent pain. Approximately 25 to 50 percent of seniors experience chronic pain so it must be reasoned that statistics for dementia patients must be similar. Chronic pain can contribute to depression, aggression, and poor cognition and should not be overlooked in dementia patients.
Therapy and Caregiver Services
Nonpharmalogical therapy methods may be directed for dementia patients through music therapy (for mental stimulation), behavioral therapy (for depression), and psychomotor therapy (for agitation). Other mental stimulation therapies may include: simple games, picture observation, reading to patients, and other techniques. Physical exercise also benefits patients. Trained caregivers may initiate and participate in stimulation therapies. Having empathetic, attentive caregivers well trained in addressing the wants and needs of dementia patients is an important part of the overall treatment regimen for dementia patients. Advice, tips, and information for better caregiving for dementia patients may be found online.